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Ebook Protein Crystallography in Drug Discovery (Methods and Principles in

Protein Crystallography in Drug Discovery (Methods and Principles in Medicinal Chemistry)




Author: Robert E. Babine
Type: eBook
Date Released: 2004
Format: pdf
Language: English
Page Count: 278
Isbn10 Code: 3527306781
Isbn13 Code: 9783527306787


Review "Medicinal chemists will find the book invaluable whether they are working in an area of one of the chapters or wish to apply the methods described to other projects. Structural and computational biologists should also find it useful and thought-provoking." —Bill Gleason (ChemBioChem, August 6, 2004) "I would recommend this book as a reference for those wanting to get insight into what is important in the early stages of drug development." (Biochemistry and Molecular Education, July/ August 2004) "…an important contribution to pharmaceutical research and development." (American Journal of Therapeutics, May/June 2004) From the Back Cover The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins often forms the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method.Here, researchers from academia and from leading pharmaceutical companies present valuable first-hand information on how to obtain the desired protein structures and how to exploit crystallographic data for the drug discovery process.From the contents:Crystallography of important target classes such as kinases and proteasesStructure-based design of protease inhibitorsStructure-based design of kinase inhibitorsThe ribosome and the proteasome as drug targetsRecent methodological advances in high-throughput crystallography and microcrystallization An indispensable companion for crystallographers involved in protein structure determination as well as drug developers following the structure-based approach.

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نوشته شده در : شنبه 19 شهریور 1390  توسط : Mohammed Grimes.    نظرات() .

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